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Discriminating between Thalasssemia from patients with iron deficiciency with red blood cell measurements.


- candidate number28106
- NTR NumberNTR6780
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR26-okt-2017
- Secondary IDsNL56731.041.16 ccmo (toetsing online)
- Public TitleDiscriminating between Thalasssemia from patients with iron deficiciency with red blood cell measurements.
- Scientific TitleDiscriminating between thalassemias and iron disorders with the Laser optical rotational cell analyser (Lorrca)
- ACRONYMThalascreen
- hypothesisWith the Lorrca which measures red blood cell deformability patients with thalassemia show a different profile than patients with iron deficiency.
- Healt Condition(s) or Problem(s) studiedIron deficiency , Alpha thalassemia, Beta thalassemia, Hereditary hemochromatosis
- Inclusion criteria1. > 18 years
2. No blood transfusion within the past 3 months
3. Have alpha-thalassemia trait, homozygous alpha thalassemia, Hemoglobin H disease or other very severe forms of alpha-thalassemia, beta-thalassemia intermedia, iron deficiency anemia or hereditary hemochromatosis
4. Be able to give informed consent
- Exclusion criteria1. Suffering from a serious condition
2. Fever at time of venepuncture
3. Inflammatory condition at time of venepuncture
4. Not able to give informed consent
5. Blood transfusion in past 3 months
6. Intra venous iron therapy in past 6 months
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- Type[default]
- Studytypeobservational
- planned startdate 1-nov-2017
- planned closingdate1-nov-2019
- Target number of participants132
- InterventionsNot applicable
- Primary outcomeRed blood cell deformability
- Secondary outcomeInvestigating underlying pathophysiological mechanisms of RBCs in thalassemia and iron disorders. Correlating clinical data, morphology of RBCs, haematological parameters and iron status to red blood cell deformability.
- Timepoints1
- Trial web site
- statusplanned
- CONTACT FOR PUBLIC QUERIES M.A.E. Rab
- CONTACT for SCIENTIFIC QUERIES M.A.E. Rab
- Sponsor/Initiator University Medical Center Utrecht (UMCU)
- Funding
(Source(s) of Monetary or Material Support)
RR Mechatronics
- Publications
- Brief summaryAlpha- and beta-thalassemias are hemoglobinopathies in which a defect in alpha or beta globin chain production causes ineffective erythropoiesis and hemolysis, resulting in a microcytic anemia. Iron deficiency causes no hemolysis but results in microcytic anemia as well. Iron overload causes oxidative damage to red blood cells(RBCs). Many patients with hemoglobinopathies have either iron overload or iron deficiency. Their deformability will thus be influenced by their hemoglobinopathy and/or iron status. To delineate these interactions we will investigate changes in deformability of different hemoglobinopathies and iron status by using the Laser optical rotational cell analyser (Lorca), a next generation ektacytometer.
- Main changes (audit trail)
- RECORD26-okt-2017 - 25-nov-2017


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