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Discriminating between Thalasssemia from patients with iron deficiciency with red blood cell measurements.


- candidate number28106
- NTR NumberNTR6780
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR26-okt-2017
- Secondary IDsNL56731.041.16 
- Public TitleDiscriminating between Thalasssemia from patients with iron deficiciency with red blood cell measurements.
- Scientific TitleDiscriminating between thalassemias and iron disorders with the Laser optical rotational cell analyser (Lorrca)
- ACRONYMThalascreen
- hypothesisWith the Lorrca which measures red blood cell deformability patients with thalassemia show a different profile than patients with iron deficiency.
- Healt Condition(s) or Problem(s) studiedIron deficiency , Alpha thalassemia, Beta thalassemia, Hereditary hemochromatosis
- Inclusion criteria1. > 18 years
2. No blood transfusion within the past 3 months
3. Have alpha-thalassemia trait, homozygous alpha thalassemia, Hemoglobin H disease or other very severe forms of alpha-thalassemia, beta-thalassemia intermedia, iron deficiency anemia or hereditary hemochromatosis
4. Be able to give informed consent
- Exclusion criteria1. Suffering from a serious condition
2. Fever at time of venepuncture
3. Inflammatory condition at time of venepuncture
4. Not able to give informed consent
5. Blood transfusion in past 3 months
6. Intra venous iron therapy in past 6 months
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- Type[default]
- Studytypeobservational
- planned startdate 1-nov-2017
- planned closingdate1-nov-2019
- Target number of participants132
- InterventionsNot applicable
- Primary outcomeRed blood cell deformability
- Secondary outcomeInvestigating underlying pathophysiological mechanisms of RBCs in thalassemia and iron disorders. Correlating clinical data, morphology of RBCs, haematological parameters and iron status to red blood cell deformability.
- Timepoints1
- Trial web site
- statusplanned
- CONTACT FOR PUBLIC QUERIES M.A.E. Rab
- CONTACT for SCIENTIFIC QUERIES M.A.E. Rab
- Sponsor/Initiator University Medical Center Utrecht (UMCU)
- Funding
(Source(s) of Monetary or Material Support)
RR Mechatronics
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD26-okt-2017 - 11-nov-2017


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