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The impact of milk protein glycation on plasma amino acid responses in healthy young men


- candidate number28241
- NTR NumberNTR6843
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR21-nov-2017
- Secondary IDsNL62254.068.17 METC
- Public TitleThe impact of milk protein glycation on plasma amino acid responses in healthy young men
- Scientific TitleThe impact of milk protein glycation on plasma amino acid responses in healthy young men
- ACRONYMPro-G
- hypothesis
- Healt Condition(s) or Problem(s) studiedProtein digestion, Amino acid absorption
- Inclusion criteria15 healthy young men (18-35 y)
- Exclusion criteria- Smoking - Allergies to milk proteins - Allergies to soya products - Musculoskeletal disorders - Use of any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescribed acne medications). - Chronic use of gastric acid suppressing medication or anti-coagulants- Unstable weight over the last three months - Pathologies of the gastrointestinal tract - Strictly vegetarian diet - Blood donation in the past 2 months
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingDouble
- controlNot applicable
- groupCrossover
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 2-okt-2017
- planned closingdate2-apr-2018
- Target number of participants15
- InterventionsMilk protein powder with varying levels of protein glycation
- Primary outcomePlasma amino acids
- Secondary outcomeinsulin-, and glucose responses.
- Timepoints0-6 h
- Trial web site
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIESPhD J. Nyakayiru
- CONTACT for SCIENTIFIC QUERIESPhD L. Verdijk
- Sponsor/Initiator NUTRIM School for Nutrition, Toxicology, and Metabolism Maastricht University
- Funding
(Source(s) of Monetary or Material Support)
Friesland Campina
- Publications
- Brief summaryProtein intake is an essential stimulus for tissue replacement/growth in infants, as well as a strong regulator of muscle protein anabolism in athletes. The anabolic effect of protein ingestion is mainly determined by the plasma amino acid response after ingestion. Although some literature suggests that glycation of proteins can alter digestion and absorption of ingested proteins, this has not yet been extensively assessed in humans. The aim of this study will be to compare the plasma amino acid responses after the digestion of a milk protein powder with varying levels of protein glycation in healthy young men.
- Main changes (audit trail)
- RECORD21-nov-2017 - 2-jul-2018


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