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‘Project ‘PLING’: development of a home-based app which uses Perceptual Learning to improve vison in children with Infantile NystaGmus’


- candidate number28331
- NTR NumberNTR6881
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR11-dec-2017
- Secondary IDsNL61860.091.17 CMO Arnhem-Nijmegen
- Public Title‘Project ‘PLING’: development of a home-based app which uses Perceptual Learning to improve vison in children with Infantile NystaGmus’
- Scientific Title‘Project ‘PLING’: development of a home-based app which uses Perceptual Learning to improve vison in children with Infantile NystaGmus’
- ACRONYMPLING
- hypothesis- Extensive perceptual learning (40 sessions) results in larger training gains than short perceptual learning (10 sessions).
- Children with idiopathic infantile nystagmus (IN) show larger training gains than children with albinism accompanied by IN.
- Healt Condition(s) or Problem(s) studiedInfantile nystagmus, Albinism
- Inclusion criteriaChildren with IN:
- Age 7-18 years (n = 40)
- Diagnosis albinism (with IN) or idiopathic IN
- Binocular visual acuity ≥20/400 and < 20/20.
- No additional (neurological or motor) impairments
- Born at term with normal birth weight (≥3000 gr)

Children with normal vision:
- Age 8-18 years (n = 30)
- Binocular visual acuity ≥20/20
- Born at term with normal birth weight (>3000 gr)
- Exclusion criteriaChildren with IN:
- Received computerized visual perceptual learning before
- Neurological conditions such as cerebral visual impairment, oculomotor apraxia, hemianopia, developmental disorders.
- Visual acuity <20/400 or ≥ 20/20.

Children with normal vision:
- Motor or mental impairments
- The presence of a developmental disorder
- Binocular visual acuity <20/20
- mec approval receivedyes
- multicenter trialyes
- randomisedno
- group[default]
- TypeSingle arm
- Studytypeintervention
- planned startdate 8-jan-2018
- planned closingdate31-jul-2019
- Target number of participants70
- InterventionsComputerized visual perceptual learning
- Primary outcome- Near and distance visual acuity
- Crowding intensity
- Secondary outcome- Contrast sensitivity function
- Stereopsis
- Reading performance
- Eye movements (fixation stability and saccade execution)
- Compliance
- Training joy
- Vision related quality of life
- TimepointsT0 = pretest measurements right before training
T1 = posttest measurements directly after training
T2 = follow up measurements 6 months after training
- Trial web site
- status[default]
- CONTACT FOR PUBLIC QUERIESDr B. Huurneman
- CONTACT for SCIENTIFIC QUERIESDr B. Huurneman
- Sponsor/Initiator Radboud University Medical Center Nijmegen
- Funding
(Source(s) of Monetary or Material Support)
ZonMw, programme InSight
- Publications• Huurneman, B., Boonstra, F.N., & Goossens, J. (2017). Predictors of sensitivity to perceptual learning in children with infantile nystagmus. Investigative Ophthalmology & Visual Science, 58(10), 4261-4272.
• Huurneman, B., Boonstra, F.N., & Goossens, J. (2016). Perceptual learning in children with infantile nystagmus: effects on visual performance. Investigative Ophthalmology & Visual Science, 57(10), 4216-4228.
• Huurneman, B., Boonstra, F.N., & Goossens, J. (2016). Perceptual learning in children with infantile nystagmus: effects on 2D oculomotor behavior. Investigative Ophthalmology & Visual Science, 57(10), 4229-4238.
• Huurneman, B., Boonstra, F.N., & Goossens, J. (2016). Perceptual learning in children with infantile nystagmus: effects on reading performance. Investigative Ophthalmology & Visual Science, 57(10), 4239-4246.
- Brief summaryOur previous project has demonstrated that a computerized visual perceptual learning paradigm can improve visual performance in children with infantile nystagmus (IN). Nevertheless, there are still some problems preventing implementation: 1) the current version of the training is not suitable as a home-based app and only runs in MATLAB, 2) it is unclear how much training is needed before subjects reach optimal performance, and 3) the available vision charts to measure crowded acuity are too loosely spaced. The goal of the current project is to deliver a clinical training tool to induce substantial, long-term vision improvements in children with IN and develop a crowding app.

This project concerns: 1) an intervention study (one-arm, one group pretestposttest design), and 2) a validation study (prospective cohort study). For the intervention project, we aim to include 40 children (age 8-18-years) with the diagnosis albinism accompanied by infantile nystagmus or idiopathic infantile nystagmus. Thirty 8-18 year old children with normal vision will be included to determine testretest variability and interest agreement of the new crowding app.
- Main changes (audit trail)Group: not applicable.
- RECORD11-dec-2017 - 18-feb-2018


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