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The impact of ingesting milk versus free amino acids on muscle protein synthesis in healthy young adults


- candidate number28420
- NTR NumberNTR6941
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR9-jan-2018
- Secondary IDsMETC173047 NL63767.068.17
- Public TitleThe impact of ingesting milk versus free amino acids on muscle protein synthesis in healthy young adults
- Scientific TitleThe impact of ingesting milk versus free amino acids on muscle protein synthesis in healthy young adults
- ACRONYMMILK-AA
- hypothesisThe ingestion of free amino acids will result in higher plasma amino acid concentrations, resulting in enhanced muscle protein synthesis rates when compared with the ingestion of milk.
- Healt Condition(s) or Problem(s) studiedMuscle protein synthesis, Milk, Free amino acids
- Inclusion criteria1) Aged 18-35 y
2) BMI 18.5-27.5 kg/m2
3) Healthy, recreationally active, young adults
- Exclusion criteria1) Allergies to milk protein
2) Lactose intolerance
3) PKU disease
4) Smoking
5) Diagnosed diabetes
6) Diagnosed metabolic or intestinal disorders
7) A history of neuromuscular problems
8) Any medications known to (or may) affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications)
9) Participation in structured resistance exercise program
10) Pregnant
11) Hormone replacement therapy
12) Third generation oral contraceptives
13) Strict vegetarian
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingDouble
- controlActive
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 25-jan-2018
- planned closingdate31-dec-2018
- Target number of participants24
- Interventionsmilk versus free amino acids
- Primary outcomemuscle protein synthesis (MPS) rates
- Secondary outcomeSecondary endpoints include whole-body protein metabolism (synthesis, breakdown, oxidation, and net balance)
- Timepointsmuscle biopsies at: -120, 0, 120, 360
blood drawn at: -210, -120, -90, -60, -30, 0, 15, 30, 45, 60, 75, 90, 105, 120, 150, 180, 210, 240, 300, 360
- Trial web site
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIES Michelle Weijzen
- CONTACT for SCIENTIFIC QUERIES Michelle Weijzen
- Sponsor/Initiator Maastricht University
- Funding
(Source(s) of Monetary or Material Support)
Maastricht University
- Publications
- Brief summaryPrevious studies suggest that the form of dietary protein that is ingested can differentially facilitate protein digestion and absorption, increase plasma AA availability, and thereby augment the postprandial muscle protein synthetic response. For example, a more rapid increase in circulating plasma AA concentrations has previously been reported after the ingestion of a protein hydrolysate when compared with an intact protein. However, no significant difference in postprandial muscle protein synthesis was observed following the ingestion of a protein hydrolysate when compared to an intact protein. The objective of this research is to assess the anabolic response following ingestion of milk and free amino acids in vivo in young adults.
- Main changes (audit trail)
- RECORD9-jan-2018 - 26-jan-2018


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