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The Effects of Stress on Infraslow Brain Activity


- candidate number28419
- NTR NumberNTR6951
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR9-jan-2018
- Secondary IDsNL64173.044.17 Toetsingonline
- Public TitleThe Effects of Stress on Infraslow Brain Activity
- Scientific TitleThe Effects of Stress on Infraslow Brain Activity
- ACRONYM
- hypothesisStress affects brain function in various ways. It is also associated with an increased likelihood of seizures in patients with epilepsy. The pathophysiology of this relationship is not well understood. A candidate mechanism is infraslow brain activity. Very slow brain oscillations with frequencies below 0.1Hz have been reported to be increased during stress and recently we and others have shown that this infraslow activity (ISA) is associated with fluctuations in cortical excitability. We further hypothesize that ISA is influenced by the stress hormone cortisol.
- Healt Condition(s) or Problem(s) studiedStress
- Inclusion criteriaHealthy
Above 18 years of age.
- Exclusion criteriaNeurological disorder (e.g. epilepsy).
Pathology that influences EEG registration.
Cardiac or respiratory diseases resulting in limited exercise tolerance.
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlNot applicable
- groupCrossover
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 15-jan-2018
- planned closingdate15-jun-2018
- Target number of participants20
- InterventionsIce-water test
Physical exercise test
- Primary outcomeChanges in infraslow EEG activity after stress in comparison with a control at rest.
- Secondary outcomeRelation of ISA to cortisol levels.
Differences between responses to stress induced by the ice-water test and stress induced by physical exercise.
- TimepointsBefore and after stress
- Trial web site
- statusplanned
- CONTACT FOR PUBLIC QUERIES S.L. Brinkman
- CONTACT for SCIENTIFIC QUERIES S.L. Brinkman
- Sponsor/Initiator Medisch Spectrum Twente, University of Twente
- Funding
(Source(s) of Monetary or Material Support)
Medisch Spectrum Twente, University of Twente
- Publications
- Brief summaryStress affects brain function in various ways. It is also associated with an increased likelihood of seizures in patients with epilepsy. The pathophysiology of this relationship is not well understood. A candidate mechanism is infraslow brain activity. Very slow brain oscillations with frequencies below 0.1Hz have been reported to be increased during stress and recently we and others have shown that this infraslow activity (ISA) is associated with fluctuations in cortical excitability. We further hypothesize that ISA is influenced by the stress hormone cortisol.

Here, we will study the relationship between ISA and stress by exposing healthy volunteers to two different stressors: the ice water test and strenuous physical exercise. If this relationship between stress and ISA is indeed shown in this study, this may explain the decreased seizure threshold in patients with stress-related seizures and also offers potential as a novel biomarker for stress related cerebral pathology.
- Main changes (audit trail)6-feb-2018: METC approval.
- RECORD9-jan-2018 - 16-feb-2018


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