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Control of attention by the motor system


- candidate number28484
- NTR NumberNTR7005
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR23-jan-2018
- Secondary IDsNL64626.041.18 Universiteit Utrecht
- Public TitleControl of attention by the motor system
- Scientific TitleControl of attention by the motor system
- ACRONYMCAMS
- hypothesisCongruence between different effectors of the motor system may produce a powerful bias in the motor system, which can counteract pathological biases in the attentional system. Therefore, an intervention with congruent eye and hand movements may result in greater attenuation of neglect compared to an intervention with single eye movements (as applied in visual scanning therapy).
- Healt Condition(s) or Problem(s) studiedEye movements, Attention, Intervention, Neglect
- Inclusion criteria Clinical diagnosed symptomatic stroke (ischemic or intracerebral haemorrhagic lesion), first or recurrent, if possible verified by Magnetic Resonance Imaging (MRI) and/or Computed Tomography (CT) data
Signs of neglect:
o asymmetry between the left and right side of the stimulus field in number of missed items of at least 2 on a shape cancelation task, and/or
o a bias towards the left or right side of space on a line bisection task, and/or
o Catherine Bergego Scale score higher than 6.
18-85 years of age
Sufficient ability to comprehend and to communicate, as observed during neuropsychological assessment and/or neglect screening
Sufficient motivation to participate in a daily rehabilitation treatment programme for two weeks.
Written informed consent
- Exclusion criteriaPatients who recovered from neglect between inclusion and start of the training (i.e. no signs of neglect anymore on all baseline measurements) will be excluded
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlActive
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-apr-2018
- planned closingdate31-mei-2019
- Target number of participants60
- Interventions15 neglect patients will receive visual scanning therapy
15 neglect patients will receive a visual scanning training combined with congruent hand movements

Outcome measures for each training group will be compared to 15 stroke patients without neglected and 15 age matched healthy controls
- Primary outcomeShape cancellation task (T0, T1)
Line bisection task (T0, T1)
Visual discrimination task (T0, T1)
Catherine Bergego Scale (T0, T1)
- Secondary outcomeVisual exploration task (T0, T1)
Virtual supermarket (T0, T1)
Eye movement behavior
- TimepointsT0 = baseline measurement
T1 = measurement after all training sessions
- Trial web site
- statusplanned
- CONTACT FOR PUBLIC QUERIES J.A. Elshout
- CONTACT for SCIENTIFIC QUERIES J.A. Elshout
- Sponsor/Initiator Utrecht University (UU)
- Funding
(Source(s) of Monetary or Material Support)
NWO
- Publications
- Brief summaryAbout 30% of all stroke patients admitted in a rehabilitation centre show unilateral visuospatial neglect. This disorder is characterized by the inability to respond to sensory stimuli in the affected (left) hemispace, due to damage to the right hemisphere. Visual scanning therapy, a training aimed at provoking eye movements to the affected hemifield, is often applied to attenuate neglect. Recent views on the attentional and motor system suggest new approaches to treat neglect. Congruence between different effectors of the motor system may produce a powerful bias in the motor system, which can counteract pathological biases in the attentional system. Therefore, an intervention with congruent eye and hand movements may result in greater attenuation of neglect symptoms compared to an intervention with single eye movements (as applied in visual scanning therapy).
- Main changes (audit trail)
- RECORD23-jan-2018 - 27-mei-2018


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