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The effectiveness of cognitive behavioural therapy (CBT) versus interpersonal psychotherapy (IPT) in panic disorder without agoraphobia.


- candidate number2126
- NTR NumberNTR701
- ISRCTNISRCTN42388561
- Date ISRCTN created19-jul-2006
- date ISRCTN requested4-jul-2006
- Date Registered NTR13-jun-2006
- Secondary IDsN/A 
- Public TitleThe effectiveness of cognitive behavioural therapy (CBT) versus interpersonal psychotherapy (IPT) in panic disorder without agoraphobia.
- Scientific TitleThe effectiveness of cognitive behavioural therapy (CBT) versus interpersonal psychotherapy (IPT) in panic disorder without agoraphobia.
- ACRONYMN/A
- hypothesisTo asses the effectivity of CBT vs. IPT in panic disorder without agoraphobia.
- Healt Condition(s) or Problem(s) studiedPanic disorder
- Inclusion criteria1. main diagnosis panic disorder without agoraphobia; 2. aged between 18 and 60.
- Exclusion criteria1. co morbid psychosis or bipolar disorder; 2. the use of psychoactive drugs; 3. Intelligence Quotient (IQ) < 80; 4. insufficient knowledge of the Dutch language; 5. previous formal IPT or CBT received (for the same complaint in the past year); 6. alcohol or drugs dependency; 7. cardiovascular disease; 8. respiratory disease; 9. epilepsy.
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlActive
- groupParallel
- Type-
- Studytypeintervention
- planned startdate 5-jun-1997
- planned closingdate6-jan-2008
- Target number of participants80
- InterventionsPatients will receive 12 therapeutic sessions of either CBT or IPT. Once a week a sessions takes place ande one session takes one hour.
- Primary outcome1. panic free status (defined with panic diaries); 2. performance on a behavioural test (3 situations). Panic diaries are completed at 0 months (pre-treatment), during treatment, 3 months (post treatment), 4 months (follow up 1) and 9 months (follow up 2). Performance on the behavioural test is assessed at 0 months (pre-treatment), 4 months (follow up 1) and 9 months (follow up 2).
- Secondary outcome1. a composite measure of panic and agoraphobic measures (FQ v+a, main fobia, ASI, FOF, ); 2. a composite measure of cognitive measures (e.g. BSIQ-14, ACQ); 3. an interpersonal measure (IIP); 4. a composite measure of general psychopathology (SCL-90, STAI). The outcomes are assessed at 0 months (pre-treatment), 3 months (post treatment), 4 months (follow up 1) and 9 months (follow up 2).
- Timepoints
- Trial web siteN/A
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIES Linsey Diels
- CONTACT for SCIENTIFIC QUERIES Arnoud Arntz
- Sponsor/Initiator University Maastricht (UM), Research Institute Experimental Psychopathology (EPP), Department of Clinical, Medical, and Experimental Psychology
- Funding
(Source(s) of Monetary or Material Support)
University Maastricht (UM), Research Institute Experimental Psychopathology (EPP), Department of Clinical, Medical, and Experimental Psychology
- PublicationsN/A
- Brief summaryIn panic disorder with agoraphobia, CBT is an effective empirical based treatment approach in which exposure in vivo and cognitive therapy are important elements. In panic disorder without agoraphobia the component of exposure may not be as relevant as the cognitive component (van den Hout, Arntz, & Hoestra, 1994). In addition, a nonprescriptive treatment, stressing that panic disorder begins as a reaction to life stress, may have comparable treatment outcomes as CBT in panic disorder (Shear, Pilkonis, Cloitre, & Leon, 1994). IPT is a therapeutic approach emphasizing the role of interpersonal problems in psychiatric conditions. IPT appears to be an efficacious treatment in depressive disorder, and eating disorders. Futhermore, primary panic attacks seem to arise during times of increased interpersonal stress (Craske, Miller, Rotunda, & Barlow, 1990). Therefore, it is very interesting to investigate the effectivty of CBT versus IPT in panic disorder without arogoraphobia.
- Main changes (audit trail)
- RECORD13-jun-2006 - 18-okt-2006


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