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Prognostic factors for cartilage degeneration in the knee after meniscectomy and cruciate ligament injuries. A prospective observational MRI cohort study.


- candidate number2149
- NTR NumberNTR718
- ISRCTNISRCTN44431821
- Date ISRCTN created21-jul-2006
- date ISRCTN requested19-jul-2006
- Date Registered NTR28-jun-2006
- Secondary IDsN/A 
- Public TitlePrognostic factors for cartilage degeneration in the knee after meniscectomy and cruciate ligament injuries. A prospective observational MRI cohort study.
- Scientific TitlePrognostic factors for cartilage degeneration in the knee after meniscectomy and cruciate ligament injuries. A prospective observational MRI cohort study.
- ACRONYMPrognostic factors for knee OA development.
- hypothesisTo identify high risk patient groups for development of knee osteoarthritis (OA) in a cohort 9-10 years after meniscus, cruciate ligament and cartilage lesions.
- Healt Condition(s) or Problem(s) studiedOsteoarthritis
- Inclusion criteriaPatients who participated in the 1997 study "MRI triage for arthroscopy.".
- Exclusion criteriaPregnacy, CI for MRI: pacemaker, metal implants, IUD etc.
- mec approval receivedno
- multicenter trialyes
- randomisedno
- group[default]
- TypeSingle arm
- Studytypeobservational
- planned startdate 1-aug-2006
- planned closingdate1-mei-2009
- Target number of participants700
- Interventions1. X-ray; 2. MRI; 3. Venapunction.
- Primary outcomeTo identify high risk patient groups for development of knee osteoarthritis (OA) in a cohort 9-10 years after meniscus, cruciate ligament and cartilage lesions.
- Secondary outcomeTo determine the use of 3T MRI state of the art imaging in detecting early OA in the knee.
- Timepoints
- Trial web siteN/A
- statusplanned
- CONTACT FOR PUBLIC QUERIES K. Huétink
- CONTACT for SCIENTIFIC QUERIES K. Huétink
- Sponsor/Initiator Dutch Arthritis Association (Reumafonds)
- Funding
(Source(s) of Monetary or Material Support)
Dutch Arthritis Association (Reumafonds)
- PublicationsN/A
- Brief summaryThe proposed study is based on a 1997 collected dataset of 859 patients with knee complaints.The original data from history taking, physical examination, plain films, MRI and arthroscopy will be made available from the original database and incorporated in a new database. All 859 patients are considered eligible for this study and will be recalled for follow-up. Patients are seen at the outpatient clinic of the department of Orthopaedic Surgery of the LUMC. Physical examination, plain films and MRI will be performed. Mouthswabs, blood and urine will be taken. The patients are asked to fill in three questionnaires. In a second and last vist to the LUMC, MRI of the knee will be performed. The main aim is to identify high risk patient groups for development of knee osteoarthritis (OA) in a cohort 9-10 years after meniscus, cruciate ligament and cartilage lesions.
- Main changes (audit trail)
- RECORD28-jun-2006 - 12-nov-2008


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