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Ingestion of different protein sources before sleep to promote muscle protein synthesis after endurance exercise in young men


- candidate number28981
- NTR NumberNTR7251
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR4-jun-2018
- Secondary IDsNL64719.068.18 METC183007
- Public TitleIngestion of different protein sources before sleep to promote muscle protein synthesis after endurance exercise in young men
- Scientific TitleThe effect of whey and casein protein ingestion prior to sleep on overnight muscle protein synthesis
- ACRONYMPROsleepMITO
- hypothesis1) Pre-sleep whey protein ingestion stimulates overnight muscle protein synthesis rates
2) Pre-sleep casein protein ingestion stimulates overnight muscle protein synthesis rates
3) Pre-sleep whey and casein protein do not differ in their impact on overnight muscle protein synthesis rates.
- Healt Condition(s) or Problem(s) studiedMilk proteins, Protein digestion, Protein, Protein synthesis
- Inclusion criteria- Males
- Aged between 18-35 years
- Healthy
- 18.5 ≤ BMI ≤ 30 kg/m2
- Exclusion criteria- Smoking
- Sports/exercise > 4 sessions/week
- Lactose intolerant
- A history of neuromuscular problems
- Use of anticoagulation medication
- Recent (<1 y) participation in amino acid tracer [13C6 or 3,5-D2-tyrosine] studies
- Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription acne medications)
- mec approval receivedno
- multicenter trialno
- randomisedyes
- masking/blindingDouble
- controlPlacebo
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-aug-2018
- planned closingdate
- Target number of participants36
- Interventions1) pre-sleep whey protein ingestion
2) pre-sleep casein protein ingestion
3) water placebo ingestion
- Primary outcomeOvernight muscle protein synthesis rates
- Secondary outcome- Plasma amino acid concentrations
- Timepoints- Overnight MPS (computed from biopsy at t=0 and t=450 min)
- Plasma amino acid concentrations: t0, t30, t60, t90, t150, t210, t330 and t450 min)
- Trial web site
- status[default]
- CONTACT FOR PUBLIC QUERIES Jorn Trommelen
- CONTACT for SCIENTIFIC QUERIES Jorn Trommelen
- Sponsor/Initiator Maastricht University
- Funding
(Source(s) of Monetary or Material Support)
Campina
- Publications
- Brief summary
- Main changes (audit trail)
- RECORD4-jun-2018 - 10-jun-2018


  • Indien u gegevens wilt toevoegen of veranderen, kunt u een mail sturen naar nederlands@trialregister.nl