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Ingestion of different protein sources before sleep to promote muscle protein synthesis after endurance exercise in young men


- candidate number28981
- NTR NumberNTR7251
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR4-jun-2018
- Secondary IDsNL64719.068.18 METC183007
- Public TitleIngestion of different protein sources before sleep to promote muscle protein synthesis after endurance exercise in young men
- Scientific TitleThe effect of whey and casein protein ingestion prior to sleep on overnight muscle protein synthesis
- ACRONYMPROsleepMITO
- hypothesis1) Pre-sleep whey protein ingestion stimulates overnight muscle protein synthesis rates
2) Pre-sleep casein protein ingestion stimulates overnight muscle protein synthesis rates
3) Pre-sleep whey and casein protein do not differ in their impact on overnight muscle protein synthesis rates.
- Healt Condition(s) or Problem(s) studiedMilk proteins, Protein digestion, Protein, Protein synthesis
- Inclusion criteria- Males
- Aged between 18-35 years
- Healthy
- 18.5 ≤ BMI ≤ 30 kg/m2
- Exclusion criteria- Smoking
- Sports/exercise > 4 sessions/week
- Lactose intolerant
- A history of neuromuscular problems
- Use of anticoagulation medication
- Recent (<1 y) participation in amino acid tracer [13C6 or 3,5-D2-tyrosine] studies
- Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription acne medications)
- mec approval receivedno
- multicenter trialno
- randomisedyes
- masking/blindingDouble
- controlPlacebo
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-aug-2018
- planned closingdate1-dec-2019
- Target number of participants36
- Interventions1) pre-sleep whey protein ingestion
2) pre-sleep casein protein ingestion
3) water placebo ingestion
- Primary outcomeOvernight muscle protein synthesis rates
- Secondary outcome- Plasma amino acid concentrations
- Timepoints- Overnight MPS (computed from biopsy at t=0 and t=450 min)
- Plasma amino acid concentrations: t0, t30, t60, t90, t150, t210, t330 and t450 min)
- Trial web site
- status[default]
- CONTACT FOR PUBLIC QUERIES Jorn Trommelen
- CONTACT for SCIENTIFIC QUERIES Jorn Trommelen
- Sponsor/Initiator Maastricht University
- Funding
(Source(s) of Monetary or Material Support)
Campina
- Publications
- Brief summaryA single session of exercise stimulates muscle protein synthesis rates, and to a lesser extent, muscle protein breakdown rates. However, the muscle protein net balance will remain negative in the absence of food intake. Protein ingestion stimulates muscle protein synthesis and inhibits muscle protein breakdown rates, resulting in net muscle protein accretion during the acute stages of post-exercise recovery. Therefore, post-exercise protein ingestion is widely applied as a strategy to augment post-exercise muscle protein synthesis rates and, as such, to facilitate the skeletal muscle adaptive response to exercise training. As overnight sleep is typically the longest post-absorptive period during the day, we have recently introduced the concept of protein ingestion prior to sleep as a means to augment muscle protein synthesis during overnight recovery following resistance-type exercise. However, it is currently unknown whether pre-sleep protein also promotes overnight recovery following other exercise modalities and whether the type of ingested protein modulates the response. Therefore, the current study investigates the impact of the ingestion of different protein source before sleep to promote muscle protein synthesis after endurance exercise.
- Main changes (audit trail)
- RECORD4-jun-2018 - 27-jul-2018


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