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The prevalence of Growth Hormone Deficiency in Autoimmune Thyroid Disease.


- candidate number2220
- NTR NumberNTR755
- ISRCTNISRCTN57632130
- Date ISRCTN created22-nov-2006
- date ISRCTN requested8-nov-2006
- Date Registered NTR28-aug-2006
- Secondary IDsN/A 
- Public TitleThe prevalence of Growth Hormone Deficiency in Autoimmune Thyroid Disease.
- Scientific TitleThe prevalence of Growth Hormone Deficiency in Autoimmune Thyroid Disease.
- ACRONYMN/A
- hypothesisThe prevalence of Growth Hormone Deficiency in Autoimmune Thyroid Disease is higher than in the general population
- Healt Condition(s) or Problem(s) studiedAutoimmune hypothyroidism
- Inclusion criteriaAutoimmune hypothyroidism Adequate thyroxine treatment
- Exclusion criteria1. History of hypothalamic or pituitary disease or known growth hormone deficiency
2. Pregnancy
3. Hypothyroidism after treatment for Graves' disease or surgery or I131
4. Major concurrent diseases
5. Use of medications known to interfere with the growth hormone-IGF-1 axis
6. No informed consent
7. Alcohol or drug abuse
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- Type-
- Studytypeintervention
- planned startdate 1-aug-2006
- planned closingdate1-jul-2008
- Target number of participants600
- InterventionsN/A
- Primary outcomePrevalence of growth hormone deficiency in patients with autoimmune hypothyroidism
- Secondary outcomeQuality of Life in patients with autoimmune hypothyroidism with or without growth hormone deficiency
- Timepoints
- Trial web siteN/A
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIESMD. S.A. Eskes
- CONTACT for SCIENTIFIC QUERIESProf. Dr. W.M. Wiersinga
- Sponsor/Initiator Academic Medical Center (AMC), Department of Endocrinology and Metabolism
- Funding
(Source(s) of Monetary or Material Support)
None
- PublicationsN/A
- Brief summaryAn uncommon cause of growth hormone deficiency is autoimmune (lymphocytic) hypophysitis. Autoimmune hypophysitis is frequently associated with other endocrine or non-endocrine autoimmune diseases. Data on isolated growth hormone deficiency caused by autoimmune hypophysitis are scarce and inconclusive. Isolated growth hormone deficiency, as a result of autoimmune hypophysitis, may not be that uncommon, especially in patients with autoimmune thyroid disease. Autoimmune hypothyroidism is common. Some hypothyroid patients who have been rendered euthyroid by adequate doses of thyroxin, suffer from a reduced quality of life. It is possible that these patients suffer from growth hormone deficiency and that growth hormone replacement would increase their wellbeing. In this study, we want to investigate what the prevalence is of GHD in patients with autoimmune hypothyroidism.
- Main changes (audit trail)
- RECORD27-aug-2006 - 4-dec-2006


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