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Role of proangiogenic Tie2+ monocytes (TEMs) in diabetes-associated macrovascular disease.


- candidate number29615
- NTR NumberNTR7688
- ISRCTNISRCTN no longer applicable
- Date ISRCTN created
- date ISRCTN requested
- Date Registered NTR1-okt-2018
- Secondary IDs201700731 Research register UMCG
- Public TitleRole of proangiogenic Tie2+ monocytes (TEMs) in diabetes-associated macrovascular disease.
- Scientific TitleRole of proangiogenic Tie2+ monocytes (TEMs) in diabetes-associated macrovascular disease.
- ACRONYM
- hypothesisWe hypothesize that the subpopulation of CD68+Tie2+ macrophages is increased in diabetic patients in comparison to non-diabetic individuals. These macrophages may cause an increased expression of Ang2 in plaques, thereby enhancing angiogenesis which contributes to increased plaque vulnerability.
- Healt Condition(s) or Problem(s) studiedDiabetes Mellitus Type 2 (DM type II), Macrovascular disease
- Inclusion criteriaMen and women
Age above 17 years
- Exclusion criteriaType 1 diabetes
Age below 18 years
Incompetent
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingSingle
- controlNot applicable
- groupParallel
- TypeSingle arm
- Studytypeobservational
- planned startdate 1-sep-2018
- planned closingdate1-jul-2019
- Target number of participants40
- InterventionsNot applicable.
- Primary outcome- Amount of tie2+ Monocytes (TEMs) and its relation with macrovascular disease
- Role of type 2 diabetes on TEMs expression
- Secondary outcome
- TimepointsNot applicable
- Trial web siteNot applicable
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIES M. Reijrink
- CONTACT for SCIENTIFIC QUERIES M. Reijrink
- Sponsor/Initiator University Medical Center Groningen (UMCG)
- Funding
(Source(s) of Monetary or Material Support)
- PublicationsNone yet.
- Brief summaryFfocus is on the role of adipose tissue inflammation/dysfunction on the development of vascular stiffness and calcification in T2D and CKD. Related to this central theme previously is performed a patient-related study in which monocyte subset frequencies were determined in subjects with T2D with or without macro-vascular disease (i.e. peripheral artery disease [PAD] and coronary artery disease [CAD]). In this study we observed increased numbers of Tie2+ monocytes (TEMs) within the population of CD14+CD16+ intermediate monocytes. Based on this observation we hypothesize that T2D is associated with increased numbers of TEMs that may subsequently migrate into developing atherosclerotic plaques. As TEMs are pro-angiogenic, intra-plaque recruitment of TEMs might result in enhanced angiogenesis thereby contributing to increased plaque vulnerability. To finalize this study, immunohistochemistry for Tie2-expressing cells need to be performed on atherosclerotic tissue. Staining procedure has been established and plaque tissue is available. As angiopoietin (Ang) 1 and 2 are the ligands for Tie2, levels of circulating Ang1 and Ang2 will be determined in archival plasma samples using a commercially available kit. Required stainings and ELISAs will be performed and to revise the draft manuscript.
- Main changes (audit trail)
- RECORD1-okt-2018 - 6-jan-2019


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