search  
 


Home

Who are we?

Why
register?


Signup for
registration


Online registration

Log in to register
your trial


Search a trial

NRT en CCMO

Contact

NEDERLANDS





MetaRegister
van CCT (UK)


ISRCTN-Register
van CCT (UK)


Endotracheal suctioning: open or closed?


- candidate number2247
- NTR NumberNTR770
- ISRCTNISRCTN75875670
- Date ISRCTN created28-dec-2006
- date ISRCTN requested18-dec-2006
- Date Registered NTR18-sep-2006
- Secondary IDsN/A 
- Public TitleEndotracheal suctioning: open or closed?
- Scientific TitlePrevention of cross-transmission of antibiotic-resistant pathogens by using closed instead of open endotracheal suction systems in mechanically ventilated intensive care patients.
- ACRONYMES-trial
- hypothesisCross-transmission of antibiotic-resistant pathogens can be prevented by using closed suction systems (CSS) instead of open suction systems (OSS) in mechanically ventilated ICU patients.
- Healt Condition(s) or Problem(s) studiedMechanical ventilation, complications
- Inclusion criteriaAll adult ICU patients receiving MV will be included and, during 6 months, be subjected to the same ES-procedure.
- Exclusion criteriaNo exclusion criteria. Preference of ES system is often based on assuptions, there is currently no scientific evidence available to prefer one system over the other.
- mec approval receivedyes
- multicenter trialyes
- randomisedyes
- masking/blindingNone
- controlActive
- groupCrossover
- Type-
- Studytypeintervention
- planned startdate 1-dec-2006
- planned closingdate1-mrt-2008
- Target number of participants500
- InterventionsEndotracheal suctioning as indicated, according to a protocol, with either CSS or OSS.
- Primary outcomeOccurrence of cross-transmission (primary endpoint), defined as acquired colonization with a genetically identical pathogen with an epidemiological linkage to a potential source patient.
- Secondary outcomeLength of stay in ICU, antibiotic use, cardio-respiratory adverse events (hypoxemia, cardiac arrhythmia, damage to respiratory mucosa), mortality, the incidence of VAP and cost-efficacy.
- Timepoints
- Trial web siteN/A
- statusplanned
- CONTACT FOR PUBLIC QUERIESDrs. I.P. Jongerden
- CONTACT for SCIENTIFIC QUERIESDrs. I.P. Jongerden
- Sponsor/Initiator University medical Center Utrecht (UMCU), Department of Intensive Care
- Funding
(Source(s) of Monetary or Material Support)
ZON-MW, The Netherlands Organization for Health Research and Development
- PublicationsJongerden IP, Rovers MM, Grypdonck MH, Bonten MJ. Open and closed endotracheal suction systems in mechanically ventilated intensive care patients: a meta analysis. Crit Care Med, accepted.
- Brief summaryCross-transmission (patient to patient spread) of antibiotic-resistant bacteria frequently occurs in intensive care units (ICUs). Among mechanically ventilated patients the respiratory tract is a preferential site for colonization with such pathogens. For these patients, endotracheal suctioning (ES) is an essential and frequently performed procedure. Yet, disconnection of the ventilation system and endotracheal tube during ES exposes colonized airways and contaminated material to open air with ongoing ventilation, and creates an optimal situation for air-borne spread of pathogens and cross-transmission. Controlling spread of antibiotic-resistant pathogens is of utmost importance in ICUs. Nowadays, two systems are available for ES: the single use open suction system (OSS) and the 'newer' multiple use closed suction system (CSS). CSS is increasingly used due to presumed patient benefits with regard to adverse physiolgic events and outcome, though we could not confirm these claims upon a systematic review. Importantly, the effects of CSS on reducing cross-transmission have never been evaluated.
- Main changes (audit trail)
- RECORD18-sep-2006 - 29-dec-2006


  • Indien u gegevens wilt toevoegen of veranderen, kunt u een mail sturen naar nederlands@trialregister.nl