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Brain activation during sentence processing in Parkinson's disease: an event related fMRI-study.


- candidate number2265
- NTR NumberNTR782
- ISRCTNISRCTN18548326
- Date ISRCTN created28-dec-2006
- date ISRCTN requested18-dec-2006
- Date Registered NTR26-sep-2006
- Secondary IDsN/A 
- Public TitleBrain activation during sentence processing in Parkinson's disease: an event related fMRI-study.
- Scientific TitleBrain activation during sentence processing in Parkinson's disease: an event related fMRI-study.
- ACRONYMN/A
- hypothesisWe hypothesise that basal ganglia are involved in sentence processing whenever a sentence structure deviates from the predicted structure and this in order to inhibit the irrelevant structure and to switch to a revision process.
- Healt Condition(s) or Problem(s) studiedParkinson's disease
- Inclusion criteria1. Idiopathic Parkinson's Disease (PD)
2. Hoehn and Yahr Stage 1 to Stage 3
3. Normal vision and hearing
4. Able to give informed consent
5. Older than 40 years
6. Dutch as first language
7. Right-handed
8. Normal structural MRI scan
- Exclusion criteria1. Not optimally medicated
2. Neurostimulator
3. Implanted pump (e.g. apomorphine)
4. Dementia (MMSE-score < 25)
5. Depression (MADRS > 18)
6. Another neurological disease
7. Another akinetic-rigid disorder
8. Another movement disorder
9. No normal structural MRI scan
- mec approval receivedno
- multicenter trialno
- randomisedno
- group[default]
- Type[default]
- Studytypeobservational
- planned startdate 1-dec-2006
- planned closingdate1-dec-2007
- Target number of participants32
- InterventionsNo interventions. It is observational research with the use of FMRI (no use of invasive techniques).
- Primary outcomeFor the fMRI analysis data, a main effect of group is expected. The level of activation in the BG will be reduced in the PD patient group compared to the healthy control group. For the within subject factors we expect to find a main effect of grammaticality. In the healthy elderly subject group, we expect that the processing of the grammatical incorrect sentences will activate the BG more compared to the processing of the grammatical correct sentences. For the behaviourally data, we expect to find slower reaction times (RTs) for the processing of non-canonical ungrammatical sentences (i.e. passive sentences with a violation) in both subject groups. However the RTs will be significantly more affected in the PD group compared to the healthy elderly subject group.
- Secondary outcomeN/A
- TimepointsN/A
- Trial web siteN/A
- statusinclusion stopped: follow-up
- CONTACT FOR PUBLIC QUERIESDrs. K. Colman
- CONTACT for SCIENTIFIC QUERIESDrs. K. Colman
- Sponsor/Initiator University of Groningen, Faculty of Arts, Neurolinguistics
- Funding
(Source(s) of Monetary or Material Support)
Stichting Internationaal Parkinson Fonds
- PublicationsPresentations on conferences and articles in scientific journals.
- Brief summaryLinguistic research has revealed that some Parkinsonís disease (PD) patients demonstrate difficulties with the comprehension of syntactically complex or rather long sentences. However, it remains unclear whether cognitive limitations such as working memory (WM), attention, and information processing speed (IPS) account for the comprehension difficulties of PD (e.g. Grossman et al., 1992; Grossman et al., 2000; Grossman et al., 2002; Lee et al., 2003); or whether the impaired sentence comprehension is due to a specific grammatical processing deficit (Lieberman et al., 1992; Natsopoulos et al., 1993; Natsopoulos et al., 1991). Up until today, relatively little is known about the involvement of the BG and/or fronto-striatal system in sentence comprehension. PD is one of the disorders of the basal ganglia. In order to evidence the involvement and the function of the BG in linguistic processes, we can study this group of patients while performing language tasks. We hypothesise that whenever the structure of a sentence deviates from the predicted syntactic structure (because of for example and error), the BG are involved in order to inhibit the irrelevant structure and to switch to a revision process.
Objective:
The primary goal of this study is to understand the sentence comprehension difficulties in Dutch speaking PD patients. Secondly, we developed the two experiments to test the hypothesis that the BG are involved and play a particular role in syntactic processing.
- Main changes (audit trail)
- RECORD26-sep-2006 - 18-jan-2010


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