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A comparison of widely used clinical contrast sensitivity tests: the relation between defocus specific contrast sensitivity and higher order aberrations.


- candidate number2324
- NTR NumberNTR812
- ISRCTNISRCTN66724598
- Date ISRCTN created1-dec-2006
- date ISRCTN requested1-dec-2006
- Date Registered NTR17-nov-2006
- Secondary IDs
- Public TitleA comparison of widely used clinical contrast sensitivity tests: the relation between defocus specific contrast sensitivity and higher order aberrations.
- Scientific TitleA comparison of widely used clinical contrast sensitivity tests: the relation between defocus specific contrast sensitivity and higher order aberrations.
- ACRONYMDefocus specific contrast sensitivity and spherical aberration
- hypothesisHigher order aberrations, like spherical aberration, decreases visual performance.
- Healt Condition(s) or Problem(s) studiedNo condition, healthy person
- Inclusion criteriaNo ocular pathology.
- Exclusion criteria1. Refractive correction larger than +/- 2 D;
2. Cylindrical correction larger than 1.5 D;
3. Cylindrical axis more then 20 from the horizontal or vertical axis.
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlNot applicable
- groupParallel
- Type2 or more arms, randomized
- Studytypeintervention
- planned startdate 1-jul-2005
- planned closingdate30-jun-2006
- Target number of participants48
- InterventionsBest corrected visual acuity was determined with an ETDRS chart and the spherical aberration (SA) was measured with a wavefront analyzer (WASCA version 1.26.3, Asclepion Meditec, Jena, Germany).


The contrast sensitivity is measured with two computerized tests:
1. One with vertical sine-wave gratings (1.5-12 cpd) generated on a CRT (Cambridge Research Systems, Rochester, UK; Von Bekesy tracking method);
2. The Holladay sine-wave (1.5 -18 cpd) modulated circular lines (HACSS) (M&S Technologies, Skokie, Illinois, USA), and with six contrast sensitivity chart tests:
1. Pelli Robson contrast sensitivity test;
2. low contrast ETDRS-like optotype chart 2.5%;
3. Low contrast ETDRS-like optotype chart 10%;
4. Edge contrast sensitivity test: GECKO;
5. Edge contrast sensitivity test: GECKO-100;
6. Vector Vision. Contrast sensitivity is measured in mesopic (3 cd/m2) and photopic (160 cd/m2) conditions, using only the dominant eye.
Tests were performed at optimal refractive state of the eye and at a variety of defocus situations(-2D to 2D).
- Primary outcomeSelection of the contrast sensitivity test which predicts the spherical aberration most reliably.
- Secondary outcome1. Spherical aberration as function of age;
2. RMS as function of age;
3. Contrast sensitivity as function of age;
4. Influence of defocus on contrast sensitivity.
- TimepointsN/A
- Trial web siteN/A
- statusinclusion stopped: follow-up
- CONTACT FOR PUBLIC QUERIESDrs. K.W. Gaalen, van
- CONTACT for SCIENTIFIC QUERIESDrs. K.W. Gaalen, van
- Sponsor/Initiator University Medical Center Groningen (UMCG), Department Ophtalmology, Advanced Medical Optics (AMO) Groningen BV
- Funding
(Source(s) of Monetary or Material Support)
SenterNovem
- PublicationsN/A
- Brief summaryThe relation between contrast sensitivity and spherical aberration and other higher order aberrations (RMS) will be studied in young and elderly subjects without ocular pathology. Contrast sensitivity will be assessed with the use of eight different contrast sensitivity tests at optimal focus and at positive and negative defocus. These results will be related to the higher order aberrations of the eyes.
- Main changes (audit trail)
- RECORD17-nov-2006 - 26-nov-2008


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