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Cognitive Therapy vs. Interpersonal Therapy for depression; Effectiveness, Relapse Prevention and Mechanisms of Change.


- candidate number2366
- NTR NumberNTR838
- ISRCTNISRCTN67561918
- Date ISRCTN created16-jan-2007
- date ISRCTN requested29-dec-2006
- Date Registered NTR13-dec-2006
- Secondary IDsN/A 
- Public TitleCognitive Therapy vs. Interpersonal Therapy for depression; Effectiveness, Relapse Prevention and Mechanisms of Change.
- Scientific TitleCognitive Therapy vs. Interpersonal Therapy for depression; Effectiveness, Relapse Prevention and Mechanisms of Change.
- ACRONYMSTEP-D
- hypothesisAre CBT and IPT following initial treatment effective interventions that prevent relapse of recurrence of depression in the long-term? What are the mechanisms of change in CBT and IPT?
- Healt Condition(s) or Problem(s) studiedDepression
- Inclusion criteria1. One or more episodes of MDD in past two years; 2. Initial treatment for depressive symptoms; 3. Residual symptoms of depression (BDI>=10).
- Exclusion criteria1. Chronic depression; 2. Concurrent treatment for depression; 3. Severe co-morbidity; 4. Medical conditions that explain depressive symptoms.
- mec approval receivedyes
- multicenter trialno
- randomisedyes
- masking/blindingNone
- controlActive
- groupParallel
- Type[default]
- Studytypeintervention
- planned startdate 1-aug-2006
- planned closingdate1-aug-2011
- Target number of participants180
- InterventionsCognitive behaviour therapy (CBT), N=75; Interpersonal therapy (IPT), N=75 8-week waiting list, N=30. CBT= max. 20 sessions IPT= max. 20 sessions All interventions are delivered by qualified therapists under supervision at the Academic Riagg Maastricht.
- Primary outcomeDepressive relapse/recurrence in the course of 24 months.
- Secondary outcome1. Severity of depression (BDI); 2. Psychological problems; 3. Health care consumption; 4. Explicit and implicit mechanism of change measures.
- Timepoints
- Trial web sitewww.emium.nl/stepd
- statusopen: patient inclusion
- CONTACT FOR PUBLIC QUERIESMSc. Lotte Lemmens
- CONTACT for SCIENTIFIC QUERIESDr. M.J.H. Huibers
- Sponsor/Initiator University Maastricht (UM), Department of Medical Clinical and Experimental Psychology (DMKEP), Academic RIAGG Maastricht
- Funding
(Source(s) of Monetary or Material Support)
University Maastricht (UM), Academic RIAGG Maastricht
- PublicationsN/A
- Brief summaryAlthough psychotherapy and antidepressants seem to help initially, many depressed patients suffer from relapse and recurrence. Recent findings suggest cognitive behaviour therapy (CBT) may reduce that risk in the long-term, but the mechanisms of change that prevent relapse and recurrence are still unknown. We will be the first to study the effectiveness of CBT compared to interpersonal therapy (IPT) for residual depression after initial treatment (reduction of symptoms; prevention of relapse and recurrence) and the underlying mechanisms of change (explicit and implicit measures). Participants will partly be recruited from an ongoing treatment study in primary care. These patients with residual depression will be offered psychotherapy (CBT or IPT) at our clinical site.
- Main changes (audit trail)
- RECORD13-dec-2006 - 12-mei-2011


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