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The marker study


- candidate number2473
- NTR NumberNTR909
- ISRCTNISRCTN35472475
- Date ISRCTN created7-mrt-2007
- date ISRCTN requested6-mrt-2007
- Date Registered NTR16-feb-2007
- Secondary IDsN/A 
- Public TitleThe marker study
- Scientific TitleMarkers of endothelial activation and damage in haematological patients in relation to efficacy of transfusion support: a pilot study.
- ACRONYMthe marker study
- hypothesisEfficacy of transfusion support depends on disease and treatment related patient factors. Markers of endothelial damage have been identified, but till today not in relation to the efficacy of transfusions.
- Healt Condition(s) or Problem(s) studiedHemato-oncological patients, Sickle cell disease, Hematological patients
- Inclusion criteria1. Age > 18 years; 2. Hemato-oncological disease; 3. Sickle cell disease; 4. Informed consent
- Exclusion criteria1. Active cardiovascular disease; 2. Recent thrombo-embolism.
- mec approval receivedno
- multicenter trialno
- randomisedno
- groupParallel
- Type-
- Studytypeintervention
- planned startdate 1-apr-2007
- planned closingdate1-apr-2008
- Target number of participants40
- InterventionsNone
- Primary outcomeEfficacy of platelet transfusion or red blood cell exchange transfusion in hemato-oncological patients and sickle cell patients, respectively, in relation to several endothelial activation markers.
- Secondary outcomen.a.
- Timepoints
- Trial web sitenone
- statusplanned
- CONTACT FOR PUBLIC QUERIESM.D. J.L.H. Kerkhoffs
- CONTACT for SCIENTIFIC QUERIESProf. Dr. A. Brand
- Sponsor/Initiator Sanquin Blood Bank South West Region
- Funding
(Source(s) of Monetary or Material Support)
Sanquin Southwest
- PublicationsN/A
- Brief summary20 patients with a hemato-oncological diagnosis and 20 patients with sickle cell disease will be asked to participate. After informed consent two blood samples will be drawn, before and after intervention (platelet transfusion and red blood cell exchange respectively). These samples will be used to test several known markers of endothelial cell activation/damage in a pilot study.
- Main changes (audit trail)
- RECORD16-feb-2007 - 7-mrt-2007


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