| - candidate number | 2598 |
| - NTR Number | NTR981 |
| - ISRCTN | ISRCTN84188372 |
| - Date ISRCTN created | 27-jun-2007 |
| - date ISRCTN requested | 11-jun-2007 |
| - Date Registered NTR | 23-mei-2007 |
| - Secondary IDs | |
| - Public Title | Carbon monoxide and Compound A measurements with desflurane and sevoflurane anesthesia in humans: an observational study. |
| - Scientific Title | Carbon monoxide and Compound A measurements with desflurane and sevoflurane anesthesia in humans: an observational study. |
| - ACRONYM | N/A |
| - hypothesis | The purpose of this study is to register the average CO concentrations in forty patients receiving desflurane or sevoflurane anesthesia after implementation of a safety protocol to prevent desiccation of the strong base containing absorbent Drägersorb 800 Plus®. |
| - Healt Condition(s) or Problem(s) studied | Carbon monoxide, Carbon dioxide, Desiccation, Anesthesia |
| - Inclusion criteria | 1. Non-smoking patients; 2. American Society of Anesthesiologists physical status class 1 to 3 scheduled for a surgical procedure that would last at least ninety minutes. |
| - Exclusion criteria | 1. Younger than 18 years of age; 2. Suffering from terminal renal failure. |
| - mec approval received | yes |
| - multicenter trial | no |
| - randomised | no |
| - group | [default] |
| - Type | Single arm |
| - Studytype | observational |
| - planned startdate | 1-aug-2005 |
| - planned closingdate | 1-okt-2006 |
| - Target number of participants | 40 |
| - Interventions | Desflurane or sevoflurane anesthesia. |
| - Primary outcome | Amount of carbon monoxide or compound A produced. |
| - Secondary outcome | N/A |
| - Timepoints | N/A |
| - Trial web site | N/A |
| - status | stopped: trial finished |
| - CONTACT FOR PUBLIC QUERIES | C. Keijzer |
| - CONTACT for SCIENTIFIC QUERIES | R.S.G.M. Perez |
| - Sponsor/Initiator | VU University Medical Center, Department of Anesthesiology |
| - Funding (Source(s) of Monetary or Material Support) | VU University Medical Center |
| - Publications | |
| - Brief summary | All modern vapor anesthetics are capable of carbon monoxide (CO) production as a result of interaction with desiccated strong base containing carbon dioxide absorbents. In desiccated absorbents, desflurane produces the highest concentrations of CO. Sevoflurane is known to produce the nephrotoxic compound A (CA) independent of the water content of the carbon dioxide absorbent. The purpose of this study is to register the average CO concentrations in forty patients receiving desflurane or sevoflurane anesthesia after implementation of a safety protocol adapted from Woehlck et al., developed to prevent desiccation of the strong base containing absorbent Drägersorb 800 Plus® while still maintaining the possibility of flushing the ventilating circuits of the anesthesia machines with a flow of air. |
| - Main changes (audit trail) | |
| - RECORD | 23-mei-2007 - 9-sep-2009 |
- Indien u gegevens wilt toevoegen of veranderen, kunt u een mail sturen naar nederlands@trialregister.nl