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van CCT (UK)


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van CCT (UK)


Carbon monoxide and Compound A measurements with desflurane and sevoflurane anesthesia in humans: an observational study.


- candidate number2598
- NTR NumberNTR981
- ISRCTNISRCTN84188372
- Date ISRCTN created27-jun-2007
- date ISRCTN requested11-jun-2007
- Date Registered NTR23-mei-2007
- Secondary IDs 
- Public TitleCarbon monoxide and Compound A measurements with desflurane and sevoflurane anesthesia in humans: an observational study.
- Scientific TitleCarbon monoxide and Compound A measurements with desflurane and sevoflurane anesthesia in humans: an observational study.
- ACRONYMN/A
- hypothesisThe purpose of this study is to register the average CO concentrations in forty patients receiving desflurane or sevoflurane anesthesia after implementation of a safety protocol to prevent desiccation of the strong base containing absorbent Drägersorb 800 Plus®.
- Healt Condition(s) or Problem(s) studiedCarbon monoxide, Carbon dioxide, Desiccation, Anesthesia
- Inclusion criteria1. Non-smoking patients;
2. American Society of Anesthesiologists physical status class 1 to 3 scheduled for a surgical procedure that would last at least ninety minutes.
- Exclusion criteria1. Younger than 18 years of age;
2. Suffering from terminal renal failure.
- mec approval receivedyes
- multicenter trialno
- randomisedno
- group[default]
- TypeSingle arm
- Studytypeobservational
- planned startdate 1-aug-2005
- planned closingdate1-okt-2006
- Target number of participants40
- InterventionsDesflurane or sevoflurane anesthesia.
- Primary outcomeAmount of carbon monoxide or compound A produced.
- Secondary outcomeN/A
- TimepointsN/A
- Trial web siteN/A
- statusstopped: trial finished
- CONTACT FOR PUBLIC QUERIES C. Keijzer
- CONTACT for SCIENTIFIC QUERIES R.S.G.M. Perez
- Sponsor/Initiator VU University Medical Center, Department of Anesthesiology
- Funding
(Source(s) of Monetary or Material Support)
VU University Medical Center
- Publications
- Brief summaryAll modern vapor anesthetics are capable of carbon monoxide (CO) production as a result of interaction with desiccated strong base containing carbon dioxide absorbents. In desiccated absorbents, desflurane produces the highest concentrations of CO. Sevoflurane is known to produce the nephrotoxic compound A (CA) independent of the water content of the carbon dioxide absorbent. The purpose of this study is to register the average CO concentrations in forty patients receiving desflurane or sevoflurane anesthesia after implementation of a safety protocol adapted from Woehlck et al., developed to prevent desiccation of the strong base containing absorbent Drägersorb 800 Plus® while still maintaining the possibility of flushing the ventilating circuits of the anesthesia machines with a flow of air.
- Main changes (audit trail)
- RECORD23-mei-2007 - 9-sep-2009


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