| - candidate number | 2599 |
| - NTR Number | NTR986 |
| - ISRCTN | incomplete |
| - Date ISRCTN created | 23-mei-2007 |
| - date ISRCTN requested | |
| - Date Registered NTR | 23-mei-2007 |
| - Secondary IDs | |
| - Public Title | Treatment in the Rotterdam Early Arthritis Cohort. |
| - Scientific Title | N/A |
| - ACRONYM | (T)REACH |
| - hypothesis | Can an early, intensive and efficient treatment prevent the cause of a persistent chronic arthritis (erosive or non-erosive) in patients who recently developed an arthritis? |
| - Healt Condition(s) or Problem(s) studied | Rheumatoid arthritis |
| - Inclusion criteria | 1. Informed consent; 2. Objectivated arthrites in at least 1 joint and at least 2 of the following criteria: a. Morningstifness>60 min; b. spec sumpt. in hand and feet; c. unexpalined shoeproblems; d. unexplained ringproblems; e. tangential pressure pain in MCP/MTP; f. pos familyanamneses; g. symm. presentation(50% of the joints); h. unexplained fatigue. |
| - Exclusion criteria | 1. Complaints existing >1 year; 2. Complaints after trauma or overburden; 3. None-rheumatic inflammatoire or systemic desease; 4. Non-communicable. |
| - mec approval received | yes |
| - multicenter trial | yes |
| - randomised | yes |
| - masking/blinding | Single |
| - control | Not applicable |
| - group | Parallel |
| - Type | 2 or more arms, randomized |
| - Studytype | intervention |
| - planned startdate | 15-jun-2007 |
| - planned closingdate | 15-jul-2011 |
| - Target number of participants | 810 |
| - Interventions | High probability (chance pers arthr >70%): groupe 1: MTX+SSZ+HCQ+1xcorticosteroids intramusc; groupe 2: MTX+SSZ+HCQ+corticosteroids; groupe 3: MTX+corticosteroids. Intermediate prob.(chance pers arthr <=30. |
| - Primary outcome | N/A |
| - Secondary outcome | N/A |
| - Timepoints | N/A |
| - Trial web site | N/A |
| - status | open: patient inclusion |
| - CONTACT FOR PUBLIC QUERIES | Prof. dr. J.T. Dissel, van |
| - CONTACT for SCIENTIFIC QUERIES | Prof. dr. J.T. Dissel, van |
| - Sponsor/Initiator | |
| - Funding (Source(s) of Monetary or Material Support) | |
| - Publications | N/A |
| - Brief summary | N/A |
| - Main changes (audit trail) | |
| - RECORD | 23-mei-2007 - 28-apr-2008 |
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